The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. You can take Trelegy Ellipta in the morning or the evening, but do not take more than one inhalation per day. For more details: See Dosage and Administration in the full Prescribing Information. Ask your doctor or pharmacist if you do not understand these instructions. In studies, Trelegy has shown a positive effect on breathing tests (FEV1) with the first dose, but it may take several weeks or longer for your overall symptoms to improve in COPD or asthma. Do not flush. For patients who do not respond adequately to TRELEGY ELLIPTA 100/62.5/25 mcg once daily, increasing the dose to TRELEGY ELLIPTA 200/62.5/25 mcg once daily may provide additional improvement in asthma control. Store Trelegy Ellipta at room temperature between 68F and 77F (20C and 25C). Accessed Oct, 22, 2020 at https://www.drugs.com/newdrugs/fda-approves-trelegy-ellipta-fluticasone-furoate-umeclidinium-vilanterol-asthma-5350.html. However, other people dont feel or taste the medication, even if they use the inhaler properly. If you have sudden trouble breathing, your doctor will likely want you to use a rescue inhaler such as albuterol (Ventolin HFA, ProAir) or levalbuterol (Xopenex). LAMA and LABA medicines are anticholinergic drugs that help to relax the muscles around the airways in the lungs. Its available only as a brand-name medication. This medication is taken as one inhalation (puff) of Trelegy Ellipta once each day. You should avoid using these medications for at least 2 weeks before you start Trelegy Ellipta treatment. The combination of drugs works to control COPD or asthma symptoms over time. Medicines that interact with Trelegy Ellipta may either decrease its effect, increase its side effects, or change how other medicines work. N Engl J Med. Taking these medications together may increase your risk for side effects. Also tell them about any vitamins, herbs, and supplements you use. Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. Primary treatment of status asthmaticus or other acute episodes of COPD or asthma where intensive measures are required. 4. It is used once daily to help breathing symptoms and reduce the number of asthma or COPD flare-ups over the long-term. Its the first FDA-approved medication containing three active drugs that can be used once a day for either COPD or asthma. Note: Trelegy Ellipta is meant to be used over time to control COPD symptoms. This is compared with 3% to 7%* of people who took only fluticasone and vilanterol (two of the three ingredients in Trelegy Ellipta). Trelegy Ellipta (generic name: fluticasone furoate/umeclidinium/vilanterol) is a once-daily triple drug inhaler approved for long-term use in asthma or chronic obstructive pulmonary disease (COPD) and must be used daily to be effective. Trelegy Ellipta is an option for the treatment of asthma in patients not controlled on inhaled corticosteroids and long-acting beta agonists alone. Drink plenty of fluids. There arent any herbs or supplements that have been specifically reported to interact with Trelegy Ellipta. changes in voice quality, such as hoarseness. Trelegy Ellipta is a long-term treatment that will work over time to ease COPD and asthma symptoms and help you breathe easier. For patients who do not respond adequately to TRELEGY 200 once daily, re-evaluate and consider other therapeutic regimens and additional therapeutic options. * This strength of Trelegy Ellipta is abbreviated as 100/62.5/25 mcg. The half-life of fluticasone furoate is about 24 hours. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Call your doctor for medical advice about side effects, precautions or warnings. Trelegy Ellipta is not used as a fast-acting inhaler for the relief of acute breathing emergencies. And some of these side effects can become serious, such as overheating or hallucinating. Its important that even if you dont feel or taste your dose, you dont take another dose. urinary tract infection *. Trelegy and Breo are the names of the medications inside the inhalers. Theres no human data available to determine if any or all of the ingredients in the medication are safe for use while pregnant. Trelegy Ellipta is approved for use in adults ages 18 years and older. The exceptions are Arnuity Ellipta, Asmanex, and Trelegy Ellipa, which last for 24. Note: You shouldnt use Trelegy Ellipta to treat sudden breathing problems caused by COPD or asthma. If you develop symptoms of thrush, be sure to see your doctor. Trelegy is only inhaled once per day because the medication effect lasts for at least 24 hours. Drugs.com. These lists dont include all possible side effects. Results showed a 25% reduction in the annual rate of flare-ups vs. Anoro, and a 15% reduction in the annual rate of flare-ups vs. Breo. TRELEGY in COPD: data from two 12-week studies and a 52-week long-term study Across two 12-week studies in subjects with COPD, the most commonly reported adverse reactions with 1% incidence and more common than BREO were: Long-term safety data: 52-week study in subjects with COPD This may cause the anti-inflammatory effects that are seen with fluticasone treatment. Fluticasone furoate is metabolized mainly by cytochrome P450 (CYP) 3A4. You should take one puff of Trelegy Ellipta once a day at about the same time each day. Trelegy Ellipta is meant to be used as a long-term treatment. Examples of tricyclic antidepressants include: If youre taking an antidepressant, talk with your doctor before you start using Trelegy Ellipta. If youre not sure if youll need to get prior authorization for Trelegy Ellipta, contact your insurance company. Chronic bronchitis is a. Its used to treat chronic obstructive pulmonary disease (COPD) and asthma. The expiration date helps guarantee that the medication is effective during this time. Bronchodilation is important in the treatment of COPD or asthma, as it helps to let more air into the lungs and allows for easier breathing. Trelegy Ellipta is approved in two strengths for use in asthma: 100/62.5/25 mcg and 200/62.5/25 mcg, while only the 100/62.5/25mcg strength is approved in COPD. The drug can also make a certain type of glaucoma called narrow-angle glaucoma worse. With emphysema, your lungs are damaged and have trouble passing air in and out. There have been reports of severe allergic reactions occurring in people with milk protein allergies who took other powder medications with lactose in them. Trelegy Ellipta is indicated for use in adults with either chronic obstructive pulmonary disease (COPD) or asthma. A certain type of diuretic called a non-potassium sparing diuretic can cause a decrease in your potassium level. Told me absolutely not to use Spiriva and Symbicort - which have worked well for me. The insurance company will review the information and let you and your doctor know if your plan will cover Trelegy Ellipta. Speak to your doctor or pharmacist about how drug interactions should be managed. These foil strips hold Trelegy Elliptas active drugs as follows: Note: After you inhale a dose of Trelegy Ellipta, be sure to rinse your mouth with water and spit out the water without swallowing. After oral administration, 70% of the drug was recovered in urine and 30% was recovered in feces. The use of Trelegy Ellipta and Breo Ellipta in treating COPD has been directly compared in a clinical study called the IMPACT trial. For more information, see the Trelegy Ellipta for asthma section below. Your doctor or pharmacist can help you take your first dose or show you the proper technique. sore throat. "Trelegy" is the name of the medication inside the inhaler. Trelegy Ellipta is contraindicated for use in people with severe milk protein allergies. In clinical trials, Trelegy Ellipta was effective in treating COPD. If you no longer need to take Trelegy Ellipta and have leftover medication, its important to dispose of it safely. Tell them about all prescription, over-the-counter, and other drugs you take. However, be sure to take the dosage your doctor prescribes for you. Its FDA-approved for the long-term maintenance treatment of: However, Trelegy Ellipta isnt approved for use as a rescue inhaler to ease sudden breathing problems caused by either COPD or asthma. The combination of these medications can cause a problem with your heart rhythm. Trelegy Ellipta is a brand-name prescription medication. Trelegy Ellipta (generic name: fluticasone furoate / umeclidinium / vilanterol) is an inhaler for asthma or COPD and must be used daily to be effective. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The medication is in a powder form that you breathe into your lungs. The lost dose will still be in the inhaler, but its not possible for you to take two doses with one puff. Trelegy Ellipta may cause headaches. Trelegy Ellipta contains three active drug ingredients: fluticasone, umeclidinium, and vilanterol. Its not known if Trelegy Ellipta is safe to take during pregnancy. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. It is not known if the medicines in Trelegy Ellipta will harm your unborn baby or pass into your breast milk and harm your baby. However, its possible that alcohol may worsen chronic obstructive pulmonary disease (COPD) or asthma symptoms, which Trelegy Ellipta is used to treat. Breo is a brand-name prescription medication. Lung function improvements (change from baseline in trough forced expiratory volume over one second [FEV1] at month 12) were also significant in the study. mild allergic reaction *. If you think youve taken too much of this drug, call your doctor. Based on a survey for secondary outcomes, Trelegy also improved patients health-related quality of life when compared to Breo, which included items such as daily symptoms, daily activities and perceived well-being. The following medications are antimicrobials that can interact with Trelegy Ellipta: If you take any antimicrobial medications, especially the ones in the list above, talk with your doctor. They can recommend ways to help ease the pain. Step 1: Prepare a dose Wait to open the cover until you are ready to take your dose. How do I store Trelegy Ellipta? With chronic bronchitis, you develop a cough that lasts a long time. Umeclidinium is minimally orally absorbed. Avoid storing this medication in areas where it could get damp or wet, such as in bathrooms, as it is a dry powder inhaler. In studies of patients with asthma, a significant improvement in lung function (FEV-1) was seen at 24- and 52-weeks when compared to the use of Breo (fluticasone and vilanterol). Therefore, these medications can cause some similar and some different side effects. Studies also showed that treatment with Trelegy Ellipta decreased the risk of COPD exacerbations (flare-ups of COPD symptoms). monthly price at. Examples of rescue inhalers include albuterol (Ventolin HFA, ProAir) and levalbuterol (Xopenex). You can prevent thrush from developing by always rinsing your mouth after you take your dose of Trelegy Ellipta. We simply charge $49 a month per medication to cover the cost of our services. For more information about what these drugs do, see the How Trelegy Ellipta works section below. This date is typically 1 year from the date they dispensed the medication. This medication is taken as one inhalation. This helps to lessen symptoms like wheezing, coughing, chest tightness or shortness of breath, all of which make it hard to breath. Using Trelegy Ellipta for a long time can raise eye pressure, worsen glaucoma, and cause cataracts (cloudiness in the eyes). If you have headaches that are bothersome to you during your Trelegy Ellipta treatment, talk with your doctor. Medically reviewed by Leigh Ann Anderson, PharmD. Avoid storing this medication in areas where it could get damp or wet, such as in bathrooms. What drugs are contained in Trelegy Ellipta? If you miss a dose of Trelegy Ellipta, take it as soon as you remember, and then take your next dose at your usual time. As with most drugs, some people can have an allergic reaction after taking Trelegy Ellipta. Below are examples of these side effects. Trelegy is only inhaled once per day because the medication effect lasts for at least 24 hours. GSK Press Release. In asthma patients: common cold symptoms (13% to 15%), rhinitis (runny or stuffy nose), painful and frequent urination (signs of a urinary tract infection), upper respiratory tract infection (3% to 6%), bronchitis (3% to 5%), flu, respiratory tract infection, headache (5% to 9%), inflammation of the sinuses, and back pain. fluticasone furoate/umeclidinium/vilanterol, chronic obstructive pulmonary disease (COPD), full product information for Trelegy Ellipta here. Revised 5/2022. Some drugs can prolong (lengthen) a part of your heart rhythm called the QT interval. However, this doesnt mean that Trelegy Ellipta will be present in human breast milk. 2018;378(18):1671-1680. A diuretic (water pill) helps your body get rid of extra water and salt. There are a total of 30 doses in each Trelegy Ellipta inhaler. There have been reports of serious allergic reactions, including anaphylaxis, when people with milk allergies take Trelegy Ellipta. This can cause an infection in your lungs and make it hard for you to breathe. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. How long do they stay in your system? Blocking these mediators can also decrease inflammation in the airways. This medication works mainly in your lungs and isnt absorbed well into your body. If you take umeclidinium with another anticholinergic medication, the drugs effects can combine and increase your risk for side effects. Trelegy Ellipta can interact with several other medications. Therefore, these medications can cause some very similar side effects. It can improve symptoms of COPD for better breathing and to reduce the number of flare-ups (the worsening of your COPD symptoms). The maximum recommended dosage is 1 inhalation of Trelegy Ellipta 200/62.5/25 mcg once daily. Refer to the prescribing information for Trelegy Ellipta for a complete list of interactions. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. The word Ellipta refers to the specific type of inhaler that contains the drug. Improvements in lung function have also been seen when Trelegy was compared to Symbicort Turbuhaler in 24-week studies or with Symbicort plus Spiriva in 12 week studies. But if your symptoms are severe, call 911 or go to the nearest emergency room right away. Common medications that may interact with Trelegy Ellipta include: Always tell your doctor and pharmacist about all the medicines you take, including prescription medicines, over-the-counter drugs, vitamins, and herbal dietary supplements. (For more about anticholinergics, see Trelegy Ellipta and other anticholinergic medications right below.). The drug isnt meant to be used for sudden breathing problems caused by COPD. Symptoms of a severe allergic reaction can include: Call your doctor right away if you have a severe allergic reaction to Trelegy Ellipta. For information about the effectiveness of Trelegy Ellipta, see the Trelegy Ellipta for COPD and Trelegy Ellipta for asthma sections below. Spiriva (tiotropium) is a brand-name drug that's used to treat COPD and asthma. Once opened, the inhaler is only good for 6 weeks. If you would like to report to the FDA a side effect youve had with Trelegy Ellipta, you can do so through MedWatch. If you dont use all 30 doses in 6 weeks, the inhaler is expired and you should throw it away. Some people do feel or taste Trelegy Ellipta after taking it. Together, these drugs work in the body to decrease inflammation and increase the space in the airways to allow more air into the lungs.